Ketamine Urology Research Studies

2007

• Shahani R, Streutker C, Dickson B. Ketamine associated with ulcerative cystitis: a new clinical entity. Urology 2007: 69:810-812 
• Chu PS, Kwok SC, Lam KM “Street-ketamine” associated ulcerative cystitis: a new clinical entity.Hong Kong Med J 2007; 13:S1-3 

2008

• Colebunders B, Van Erps P Cystitis due to the use of ketamine as a recreation drug: a case report. J Med Case Reports 2008 June 26;2:219 
• Tsai JH, Tsai KB, Jan MY Ulcerative cystitis associated with ketamine. Am. J. Addict 2008 Sept-Oct;17(5):453 
• Gregoire MC, MacLellan D Finley D A pediatric case of ketamine-associated cystitis 9letter to the editor RE: Shahani R, et al: ketamine associated ulcerative cystitis: A new clinical entity. UrologyVolume 71, Issue 6 (June 2008) 
• Chu PS, et al.  The destruction of the lower urinary tract by ketamine abuse: a new syndrome? BJU Int 2008 Dec;102(11):1616-22 

2009

• Gillatt D. Painful Bladder and Urinary Tract Pathology Associated with Long Term Ketamine Use. Poster #208 ICS 2009 Annual Meeting 
• Yeong-Woei C, Chwel-Shiun Y. The Case: Disabling frequent urination in a young adult. Kidney International 2009 76,123-124. 
• Tsai TH et al. Ketamine-associated bladder dysfunction. Int J Urol. 2009 Oct;16(10):826-9. Epub 2009 Jul 29. 
• Wong SW et al. Dilated common bile ducts mimicking choledochal cysts in ketamine abusers. Hong Kong Med J. 2009 Feb;15(1):53-6. 
• Yeung LY et al. Mice are prone to kidney pathology after prolonged ketamine addiction. Toxicol Lett.2009 Dec 15;191(2-3):275-8. 
• Oxley JD, et al. Ketamine cystitis as a mimic of carcinoma in situ. Histopathology. 2009 Dec;55(6):705-8. 

2010

• Noorzurani R, et al.  Illicit ketamine induced frequency of micturition in a young Malay woman. Drug Alcohol Rev. 2010 May;29(3):334-6. 
• Mason K, et al. Ketamine-associated lower urinary tract destruction: a new radiological challenge.Clin Radiol. 2010 Oct;65(10):795-80 

2011

• Liao Y, et al. Reduced dorsal prefrontal gray matter after chronic ketamine use. Biol Psychiatry. 2011 Jan 1;69(1):42-8. 
• Wood D, et al. Recreational ketamine: from pleasure to pain. BJU Int. 2011 Feb 14. 
• Tan S. et al. Ketamine effects on the urogenital system-changes in the urinary bladder and sperm motility. Microsc Res Tech. 2011 May 11. 
• Lo RS, et al. Cholestasis and biliary dilatation associated with chronic ketamine abuse: a case series.Singapore Med J. 2011 Mar;52(3):e52-5. 
• Jang MY, et al. Sexual dysfunction in women with ketamine cystitis: a case control study. BJU Int, 2011 Dec 16. 
• Chen Ch. et al. Ketamine snorting associated cystitis. J Formos Med Assoc. 2011 Dec;110(12):787-91. Epub 2011 Dec 27. 

2012

• Garcia-LarrosaA, et al. Cystitis and ketamine associated bladder dysfunction. Actos Urol Esp. 2012 Jan; 36(1):60-4 
• Lieb M, et al. Ketamine induced vesicopathy. Psychiatr Prax. 2012 Jan;39(1):43-5. Epub 2012 Jan 10.
• Ketamine cystitis: an emerging diagnostic and therapeutic challenge.
• Ketamine-associated vesicopathy.
• Acute and chronic toxicity pattern in ketamine abusers in Hong Kong.
• Sexual dysfunction in women with ketamine cystitis: a case-control study.
• The Chinese version of the pelvic pain and urgency/frequency symptom scale: a useful assessment tool for street-ketamine abusers with lower urinary tract symptoms.
• [Cystitis and ketamine associated bladder dysfunction].
• Ketamine use: a review.
• Ketamine-Induced Uropathy: A New Clinical Entity Causing Lower Urinary Tract Symptoms.
• [Ketamine-induced vesicopathy].
• Gourd-shaped bladder associated with ketamine abuse.
• Ketamine-associated urinary tract dysfunction: an underrecognized clinical entity.
• Illicit ketamine and its bladder consequences: is it irreversible?
• The prevalence and natural history of urinary symptoms among recreational ketamineusers.

2013

• Genitourinary toxicity of ketamine.
• 'Ketamine-induced ulcerative cystitis' is perhaps better labelled 'ketamine-induced uropathy'.
• Ketamine and damage to the urinary tract.
• [Diagnosis and treatment of ketamine-associated cystitis: a report of 3 cases and literature review].
• Clinical outcomes of augmentation cystoplasty in patients suffering from ketamine-related bladder contractures.
• Effects of long-term ketamine administration on rat bladder protein levels: a proteomic investigation using two-dimensional difference gel electrophoresis system.
• Nerve hyperplasia: a unique feature of ketamine cystitis.
• Treatment of ketamine-associated cystitis with chondroitin sulphate.
• Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder.
• Increased apoptosis and suburothelial inflammation in patients with ketamine-related cystitis: a comparison with non-ulcerative interstitial cystitis and controls.

2014

• Protective effect of ketamine against hemorrhagic cystitis in rats receiving ifosfamide.
• Chronic hematuria and abdominal pain.
• Evaluation of the extent of ketamine-induced uropathy: the role of CT urography.
• Is Urodynamic Study a Good Witness to the Progression of Ketamine-Associated Cystitis?
• Bilateral hydronephrosis and cystitis resulting from chronic ketamine abuse.
• Ketamine cystitis: practical considerations in management.
• Elevated serum IgE may be associated with development of ketamine cystitis.
• [Urinary tract lesions associated to ketamine consumption].
• Augmentation enterocystoplasty is effective in relieving refractory ketamine-related bladder pain.
• Long-term ketamine abuse induces cystitis in rats by impairing the bladder epithelial barrier.
• One-stop clinic for ketamine-associated uropathy: report on service delivery model, patients' characteristics and non-invasive investigations at baseline by a cross-sectional study in a prospective cohort of 318 teenagers and young adults.
• Ketamine: an update on its abuse.
• Mast cells infiltration and decreased E-cadherin expression in ketamine-induced cystitis.

2015

• Resonance metallic ureteric stent in a case of ketamine bladder induced bilateral ureteric obstruction with one year follow up.
• Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease.
• Biological effect of ketamine in urothelial cell lines and global gene expression analysis in the bladders of ketamine‑injected mice.
• Histopathological assessment of inflammation and expression of inflammatory markers in patients with ketamine-induced cystitis.
• Autotransplantation for the management of ketamine ureteritis.
• Alteration of Urothelial Inflammation, Apoptosis, and Junction Protein in Patients with Various Bladder Conditions and Storage Bladder Symptoms Suggest Common Pathway Involved in Underlying Pathophysiology.
• Novel Treatment of Chronic Bladder Pain Syndrome and Other Pelvic Pain Disorders by OnabotulinumtoxinA Injection.
• Clinical Outcome of a Prospective Case Series of Patients With Ketamine Cystitis Who Underwent Standardized Treatment Protocol.
• Translocation of NF-κB and expression of cyclooxygenase-2 are enhanced by ketamine-induced ulcerative cystitis in rat bladder.
• Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.
• Possible pathophysiology of ketamine-related cystitis and associated treatment strategies
• The clinical presentation and diagnosis of ketamine-associated urinary tract dysfunction in Singapore.

2016

• The fibrosis of ketamine, a noncompetitive N-methyl-d-aspartic acid receptor antagonist dose-dependent change in a ketamine-induced cystitis rat model.
• A Rare Urachal Cyst in a Case of Ketamine-induced Cystitis Provides Mechanistic Insights.
• The Role of Immunoglobulin E in the Pathogenesis of Ketamine Related Cystitis and Ulcerative Interstitial Cystitis: An Immunohistochemical Study.
• Intact urothelial barrier function in a mouse model of ketamine-induced voiding dysfunction.
• Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress.
• A REVIEW OF KETAMINE ABUSE AND DIVERSION.
• Mesenchymal stem cells protect against the tissue fibrosis of ketamine-induced cystitis in rat bladder.
• Microvascular Injury in Ketamine-Induced Bladder Dysfunction.
• Evaluation of urinary bladder fibrogenesis in a mouse model of long-term ketamineinjection.
• Abnormal Sensory Protein Expression and Urothelial Dysfunction in Ketamine-Related Cystitis in Humans.
• Pregnancy With a Successful Vaginal Delivery Following Augmentation Enterocystoplasty for Ketamine Cystitis: A Case Report.
• Ketamine: A Cause of Urinary Tract Dysfunction.

2017

• The Immunomodulatory Imbalance in Patients with Ketamine Cystitis.
• The putative involvement of actin-binding proteins and cytoskeleton proteins in pathological mechanisms of ketamine cystitis-Revealed by a prospective pilot study using proteomic approaches.
• Clinical Outcome of Augmentation Enterocystoplasty for Patients with Ketamine-induced Cystitis.
• Patient characteristics for different therapeutic strategies in the management ketaminecystitis.
• Effective treatment of ketamine-associated cystitis with botulinum toxin type a injection combined with bladder hydrodistention.
• The Risk of Upper Urinary Tract Involvement in Patients With Ketamine-Associated Uropathy.
• Elucidating Mechanisms of Bladder Repair after Hyaluronan Instillation in Ketamine-Induced Ulcerative Cystitis in Animal Model.
• Changes to the bladder epithelial barrier are associated with ketamine-induced cystitis.
• Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-β1.
• Activation of the mTOR dependent signaling pathway underlies ketamine-induced uropathy.

2018

• The Therapeutic Effect of Human Embryonic Stem Cell-Derived Multipotent Mesenchymal Stem Cells on Chemical-Induced Cystitis in Rats.
• Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis.
• The effects of recreational ketamine cystitis on urinary tract reconstruction - a surgical challenge.
• Delayed Urinary Symptoms Induced by Ketamine.
• Management of complications of ketamine abuse: 10 years' experience in Hong Kong.
• Potential Orphan Drug Therapy of Intravesical Liposomal Onabotulinumtoxin-A for Ketamine-Induced Cystitis by Mucosal Protection and Anti-inflammation in a Rat Model.
• Complete reversal of the clinical symptoms and image morphology of ketamine cystitisafter intravesical hyaluronic acid instillation: A case report.
• Risk Factors of Lower Urinary Tract Syndrome among Ketamine Users.
• Sexual and bladder dysfunction in male ketamine abusers: A large-scale questionnaire study.

2019

• Ketamine‑induced bladder dysfunction is associated with extracellular matrix accumulation and impairment of calcium signaling in a mouse model.
• Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine-induced vesicopathy.